Nootropics
Nootropics, often referred to as "smart drugs," are a class of substances that enhance cognitive function, memory, and focus. Two notable substances within this category are modafinil and armodafinil.
Nootropics, often referred to as "smart drugs," are a class of substances that enhance cognitive function, memory, and focus. Two notable substances within this category are modafinil and armodafinil.
The former has gained popularity for its wakefulness-promoting properties and is widely used off-label as a cognitive enhancer. Modafinil is known for its ability to enhance alertness and concentration without the jittery side effects commonly associated with stimulants. Armodafinil, a derivative of that medicine, offers similar benefits but provides a longer duration of effect.
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‘Nootropics’ is an umbrella term that includes diverse substances which improve cognitive abilities and bolster the mind. Modafinil and armodafinil are known to reliably raise the levels of brain activity to full wakefulness. They are very popular for heightening alertness and mental energy. Many use them for improved concentration and work efficiency.
Racetams are a group of chemicals (Piracetam and Aniracetam are two examples) that are well-known for bettering memory, raising learning capacity and improving concentration. These types of treatments have a good reputation on the market and are used mainly to treat allergies.
Choline is found in eggs, and it is the precursor of the neurotransmitter acetylcholine. Two choline supplements are CDP-Choline and Alpha GPC. Both can help to preserve cognitive function, which encompasses memory, attention and brain health in general.
Adaptogens are stress-adapting herbs like ginseng, Rhodiola rosea, and ashwagandha foster the body's adaptation to stress, mental resilience, concentration and mood stability. Natural nootropics are contained in substances like caffeine, L-theanine (that is found in tea), or the Bacopa Monnieri plant.
Most of these natural medicines can be bought over the counter, and they are used for attention issues, strengthening memory and improving cognitive function. However, the chemically synthesised nootropics are known to have the strongest action. Modafinil and armodafinil are well-studied and approved smart drugs, which allow users to remain alert, concentrated, and mentally energized.
Nootropics have been shown to effectively manage medical conditions like narcolepsy, ADHD (off-label) and shift work sleep disorder. Studies found that about 0.5% of people or 1 in 2,000 people, in UK, are experiencing narcolepsy, a neurological disorder that leads to unpredictable sleep behaviours and excessive daytime sleepiness.
The well-known nootropics modafinil and armodafinil have been approved for the standard treatment of narcolepsy. They also help wakefulness in the daytime for those suffering from unusual sleep patterns.
Non-standard Working Schedule Daytime Sleep Disorder is a problem often faced by people who work irregular shifts. Research has demonstrated that these drugs are effective in managing the tiredness that comes from going to work at inconvenient times.
According to UK polls, the prevalence of SWSD among British shift workers seems to be quite high. Up to 20% of shift workers report having to deal with symptoms. These drugs provide alertness and maintain mental acuity which enables workers to be more productive and experience fewer accidents arising from sleep deprivation.
The UK's National Institute for Health and Care Excellence (NICE) estimates that ADHD affects roughly 3% to 4% of adults. Please note that to treat ADHD is an off-label use for these treatments. Even though their effectiveness is confirmed, they have not replaced the primary medications to treat attention deficit hyperactivity disorder.
These drugs are generally well-tolerated, but users must still be aware of possible side effects. Common ones can include headaches, stomach problems, dizziness, increased urination and nausea. These effects are usually light, short-term and fade as the medication is expelled from the body.
Severe adverse reactions, although infrequent, can be possible too. Some examples are allergic reactions, skin rashes, mood changes, anxiety, insomnia, and rapid heartbeat. Managing and reducing side effects should be given priority if the user wants to have a safe experience with the treatment.
Drinking enough water will help in decreasing the chance of headaches or digestive system problems. To avoid sleep disturbances, it is advisable to take nootropics in the morning. Take care of how your body responds to nootropics and if any adverse side effects arise, seek medical attention.
If you are looking to use nootropics regularly, it can be good to take periodical breaks to avoid tolerance build-up and reduce the probability of side effects. Maintain regular communication with your doctor about any adverse reactions or concerns. They could give valuable advice, adjust the dosages, or explore other approaches if required.
Keep in mind that different people have different reactions to drugs. Through observing prescription instructions and consulting with professionals you will reduce the risk of side effects and have a safe and effective experience with nootropics.
The mode of action of nootropics is rather complex. Some would say it is not fully understood. The main theory is that they act on multiple neurotransmitters in the brain, such as dopamine, norepinephrine, and histamine.
These medicines promote wakefulness and improve cognitive functions through interactions with these neurotransmitters. This, as a result, leads to better vigilance, alertness, and concentration. In addition, nootropics regulate noradrenaline in the brain.
Norepinephrine acts as a regulator for attention and wakefulness, and all prominent cognitive enhancers have been proven to increase its levels. Another neurotransmitter that is affected by these nootropics is histamine. ‘Smart drugs’ increase histamine release, which can increase wakefulness and alertness.
It is important to point out that although their exact mechanism of action is not yet fully revealed, cognitive enhancers have been clinically proven to work, time after time. They keep the user awake without the excessive release of norepinephrine and dopamine that traditional stimulants employ. The mechanisms of ‘smart drugs’ are based on their interaction with several groups of neurotransmitters.
Resulting in increased energy, clear focus, and enhanced overall brain activity, smart drugs have a well-deserved reputation. Still, users have to keep in mind that individual responses differ, and deciphering the exact mechanism of action for these medicines is for now, an unresolved question in medical science.
It is important to consult with your GP or medical professional before taking this type of treatment for the first time. They can determine if the treatment is suitable and set a personalised dosage.
Determining the dosage of the nootropics in each individual case depends on several factors, like the user’s age, weight, and the severity of the condition being treated. There are still general guidelines for dosage, but they should be used by GPs, not by the users.
For narcolepsy and excessive daytime sleepiness, the suggested dosage of modafinil or armodafinil is one dosage or tablet once per day. This should be taken orally with a drink of water, preferably in the morning. In cases of ADHD, nootropics are sometimes used off-label under medical supervision. Doctors will determine the exact medication and dosage during consultation.
Usage guidelines are slightly different in the case of shift work sleep disorder. When working shifts, nootropics should be taken approximately one hour before work starts. This is enough time for the medication to take effect.
Another important consideration when starting a new medication is contraindications. Factors like liver or kidney impairments, other health conditions and concurrent drugs, play a determining role in administering the right dose. These conditions will be covered in detail in the safety section.
Many studies have been carried out on these drugs, both in the UK and abroad. The most prominent one is the summary of 24 studies of modafinil dated from 1990 to 2014 by University of Oxford and Harvard Medical School scientists. The study is available online and concludes that nootropics are effective.
The majority of these studies also came to reassuring conclusions about side effects - they found that popular smart drugs had very little effect on mood, which was almost negligible. ‘Modafinil may well deserve the title of the first well-validated pharmaceutical nootropic agent’, - the authors conclude.
Nootropics are not known to cause physical dependency and remain a relatively safe drug from that standpoint. That does not mean the user can self-dose or take them without a plan. As with any other treatments, people who are planning to take a strong non-organic nootropic as a course need to consult with a doctor and make sure they disclose their complete medical history, from past addictions to chronic conditions and medications currently being taken.
Contraindications with ‘smart drugs’ are quite numerous. According to the British National Formulary, they include heart conditions like LVH, unstable angina or a recent infarction. Patients previously diagnosed with liver and kidney issues or mental health issues need to practice maximum caution while using these medications.
Expectant mothers or breastfeeding persons should not use nootropics. Safety is paramount during pregnancy and only absolutely necessary treatments should be used.
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Last Reviewed: 16th September 2024
Next Review Due: October 2025
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